When New Diseases Emerge, Experts Are Faster On The Uptake

Oct 3, 2012
Originally published on October 3, 2012 11:37 am

Scientists have recently discovered three new human viruses.

One, from the Arabian Peninsula, causes severe pneumonia and kidney failure. Another sent two Missouri farmers to the hospital with severe fatigue and low blood platelets. The third, in central Africa, causes a new kind of hemorrhagic fever.

The most striking thing about all three new viruses is that they were found on the basis of just two or three human cases. That's a long way from where the world was 10 years ago, when another new virus popped up in Asia and quickly went global.

The mysterious new disease would become known as SARS — Severe Acute Respiratory Syndrome. Before it was stopped, it would strike 8,000 people around the world and kill more than 900 (amazingly, none in the U.S.).

Initially the World Health Organization thought SARS emerged in February 2003 in southern China. A physician who caught the virus there brought it to Hong Kong when he attended his son's wedding. He famously infected a globetrotting roster of tourists during his stay at the Metropole Hotel.

But that early report turned out to be wrong in one major respect. The first SARS outbreak (caused by people eating civet cats who had apparently been infected by bats) actually started four months earlier in Guangdong Province. But few knew, because Chinese authorities weren't telling.

Dr. John Brownstein of Children's Hospital in Boston says that wouldn't happen today. "Today we would have seen that information bubbling up in many different places," he says.

Brownstein and his colleagues collect real-time reports about disease outbreaks from all over the world and display them on a website called HealthMap.

"Ten years after SARS, I think it's very difficult to imagine ... an important public health event where that information isn't getting out in some form — via text messages, tweets, Facebook posts, blogs, chat rooms," he told Shots. "I think there's very few places on Earth where we're not able to get citizen reporting and information."

Dr. William Schaffner, an infectious disease specialist at Vanderbilt University, agrees. "Communication about health-related issues just travels with the speed of light today," he says. "I think the problem of international communication — openness and sharing of information — is largely resolved."

One big reason is a new set of International Health Regulations that went into effect in 2007. They require countries to report disease outbreaks right away to the World Health Organization.

Dr. Isabelle Nuttall of the WHO says the new regulations are working. And she says the agency is much better equipped to handle new diseases.

"We are much better organized," she says. "We've learned over the years. What was done for SARS as an improvisation, I would say, is not extremely well-structured."

Nuttall is coordinating the WHO's current response to the new virus that emerged in Saudi Arabia. It killed one Saudi man in June, and last month put another man from neighboring Qatar into an intensive care unit in London.

It's not clear how the two men got the new virus, which is genetically related to a virus that infects bats. They didn't know each other, and the onset of their illnesses was three months apart. But, according to Nuttall, both had been in Jeddah, a Red Sea port of 3 million that is the gateway to the holy Muslim city of Mecca.

The new microbe is a coronavirus, the same family that includes the SARS virus — and causes around 20 percent of common colds. But fortunately it appears to be far less contagious than the SARS virus.

Better communications aside, the world has another big advantage over the SARS era. Back then, it was months after its emergence before scientists even knew if the new microbe was a virus or bacterium.

In contrast, thanks to an alert pathologist in Jeddah, the new Saudi microbe was immediately identified as a new virus while the very first patient was still in the hospital.

Then, when the second patient showed up three months later, scientists in four countries got to work and figured out its full genetic code in record time.

"Today we are speaking about days to a week rather than a month" to resolve the whole genetic sequence of a new virus, says Dr. Ab Osterhaus of Erasmus University in Rotterdam, one of the scientists working on the new virus.

Knowing the genetic sequence gives researchers a lot of clues about where the virus may have come from. It also has enabled them to devise a quick and reliable diagnostic test, plus a confirmatory test, so doctors can tell if an acutely ill patient is infected with the new virus or something else.

The next step is also critical — devising a blood test to detect antibodies to the new virus. That would be important in detecting whether people who are not currently ill had been exposed to the virus in the past.

"We need a test [for antibodies], and I think a test will soon be available," Osterhaus told Shots. "That would give you eventually an indication whether the virus has been spreading at all among the population."

And that could tell scientists if some people get infected without getting sick, raising the possibility that they could infect others who might be more vulnerable. Or perhaps people can only get the new virus from an animal or insect.

Those are important questions as several million Muslims from all over the world converge on Saudi Arabia this month for the annual pilgrimage to Mecca.

Copyright 2013 NPR. To see more, visit http://www.npr.org/.

Transcript

RENEE MONTAGNE, HOST:

It's MORNING EDITION from NPR News. I'm Renee Montagne.

STEVE INSKEEP, HOST:

And I'm Steve Inskeep.

Scientists have recently discovered three new human viruses. One, from the Arabian Peninsula, causes severe pneumonia and kidney failure. Another sent two Missouri farmers to the hospital with severe fatigue and headaches. The third, in central Africa, causes a disease similar to Ebola. The unsettling part of this report is the reminder that there are new diseases to be found in the world. But this story also reveals how good experts have become at finding them. NPR's Richard Knox reports.

RICHARD KNOX, BYLINE: The most striking thing about all three new viruses - they were found on the basis of just two or three human cases. That's a long way from where the world was 10 years ago, when another new virus popped up in Asia and quickly went global. Here's an ABC News clip from mid-March of 2003.

(SOUNDBITE OF NEWS CLIP)

UNIDENTIFIED MAN: The government is scrambling to keep a mysterious and deadly disease at bay. It was first detected in China last month and has already spread through half a dozen Asian countries.

KNOX: The mysterious new disease would become known as SARS - Severe Acute Respiratory Syndrome. Before it was stopped, it would strike 8,000 people and kill more than 900 worldwide. But that early report turned out to be wrong in one major respect. SARS didn't start in February of '03. The outbreak started four months earlier in southern China, but few knew, since Chinese authorities weren't telling. Dr. John Brownstein of Children's Hospital in Boston says that wouldn't happen today.

DR. JOHN BROWNSTEIN: Today, we would have seen that information bubbling up many different places.

KNOX: Brownstein and his colleagues collect real-time reports about disease outbreaks from all over the world and display them on a website called HealthMap.

BROWNSTEIN: Ten years after SARS, I think it's very difficult to imagine a situation, an important public health event, where that information isn't getting out in some form, via text messages, tweets, Facebook posts, blogs, chat rooms. I think there's very few places on earth where we're not able to get citizen reporting and information.

DR. WILLIAM SCHAFFNER: Communication about health related issues just travels with the speed of light today.

KNOX: Dr. William Schaffner is a Vanderbilt University specialist in infectious diseases.

SCHAFFNER: I think the problem of international communication - openness and sharing of information - is largely resolved.

KNOX: One big reason is a new set of international health regulations that went into effect in 2007. They require countries to report disease outbreaks right away to the World Health Organization. Dr. Isabelle Nuttall of the W.H.O says the agency is much better equipped to handle new diseases.

DR. ISABELLE NUTTALL: We are much better organized. We've learned over the years what was done for SARS as an improvisation, I would say, is now extremely well structured.

KNOX: Nuttall is coordinating the W.H.O.'s current response to the new virus that emerged in Saudi Arabia. It killed one Saudi man in June, and last month, put another man from neighboring Qatar into an intensive care unit in London. The new virus is a relative of the one that causes SARS, but fortunately it appears far less contagious.

Better communications aside, the world has another big advantage over the SARS era. Here's another clip from that 2003 news report on SARS.

(SOUNDBITE OF NEWS CLIP)

UNIDENTIFIED MAN: Despite 10 days of testing, they still don't know whether it's caused by a virus or a bacteria.

KNOX: In contrast, the new Saudi microbe was immediately identified as a new virus in the same family as SARS while the very first patient was in a Saudi Arabian hospital. Then, when the second patient showed up three months later, scientists in four countries got to work and figured out its full genetic code in record time.

DR. AB OSTERHAUS: Today, we are speaking about days to a week, rather than a month. So we have become much faster.

KNOX: Dr. Ab Osterhaus of Erasmus University in Rotterdam is one of the scientists working on the new virus. The next step is also critical - a blood test to detect antibodies to the new virus.

OSTERHAUS: We need a test, and I think a test will soon be available. And that would give you eventually an indication on whether the virus at all has been spreading among the population.

KNOX: You could tell scientists if some people get infected without getting sick. They could infect others who might be vulnerable. Or maybe people can only get the new virus from an animal or insect. Those are important questions as several million people converge on Saudi Arabia this month for the annual pilgrimage to Mecca.

Richard Knox, NPR News. Transcript provided by NPR, Copyright NPR.